What do you know about bone marrow transplant treatment of sickle cell disease? - ecobeautyguide.com

What do you know about bone marrow transplant treatment of sickle cell disease?

Bone marrow transplantation is the only method capable of treating sickle cell disease. However, experts said this is not a simple trick. Besides the health benefits that this method brings, it is also accompanied by the risk of complications and the possibility of failure.

Sickle cell disease is a type of blood disorder is genetic. When diagnosed with this pathology, you do not have a sufficient number of red blood cells healthy to transport oxygen to go feed the organs in the body. Cells abnormal hemoglobin will have trouble moving through the small capillaries, obstructing blood circulation. This condition can lead to damaged tissues or organs do not provide enough blood.

To treat the sickle cell disease, you have only a single option is to perform bone marrow transplantation, also called stem cell transplant hematopoiesis. However, if you are planning to perform surgery bone marrow transplant for yourself or child, you need to learn about this measure.

Bone marrow transplantation treatment of sickle cell disease how?

Principles of surgery, bone marrow transplantation is replacement of the stem cell erythropoiesis by the new healthy cells. This means that your body will stop the production of these cells sickle cell cause disease.

In this procedure, the doctor will transplant the healthy stem cells from the bone marrow of a donor into your body, usually through the IV injection directly into a vein. After the transplant, the new cells will migrate to bone marrow and begin to create the red blood cells healthy.

Looks simple, but the actual bone marrow transplant is a long process. When you find a donor, you will have to enter the hospital in a few weeks and then continue to receive follow-up care a few more months. This process begins before surgery, by grafting hematopoietic stem cells takes place:

Phase 1

In the 1-2 weeks before the transplant, you will enter the hospital to perform chemotherapy. These drugs have the effect to destroy the bone marrow cells that produce the hemoglobin defect.

Besides, they also make your immune system weak. Since then, leukemia cells can hardly attack the new cells are grafted into the guide to prevent the process of graft rejection. On the other hand, you also may be asked to perform additional radiation therapy.

Phase 2

Then the doctor will proceed to transplant donor cells into your body. These cells replace the bone marrow and generate the cells a healthy. Our team of professionals take care of you will trial about a month to ensure the new cells are functioning well.

Stage 3

Once the doctors confirmed that the transplanted cells have stable operation, you can export institute. The function of the leukemia cells will need about 6-12 months or longer to return to normal. During this time, the doctor will closely monitor your health.

Find a donor

People with sickle cell disease severe, people have had many complications or the pain paralysis are good candidates for bone marrow transplantation. The doctor will have to make sure you or your child healthy enough to perform this procedure. A conversation with a professional psychologist or social worker can also help the doctor know whether you are ready mentally for the process of surgery has not.

Doctors need to find a donor whose bone marrow is compatible with you. This can be one of the biggest challenges in the process.

Blood tests will tell your doctor the marrow of siblings or parents have joint with you do not. About 20-30% of children find the donor’s relatives in the family.

In addition, the donor is also likely to be strangers. Compatibility rate will be high if the doctors took the bone marrow cells donated from the umbilical cord.

Risks of bone marrow transplant in the treatment of sickle cell disease

Similar to many treatment other health, besides the health benefits that bone marrow transplantation bring, it is also accompanied by the risk of complications and the possibility of failure. Those at risk typically include:

Transplant rejection

Transplant rejection is the term used to describe the body from rejecting organ transplant and is rejecting it. In addition, you can also face complications called the disease graft against the host (GvHD). This is the condition the new cells see the cell in your body is able to invade (pathogens) and attack them.

Typically, every 10 transplant recipients hematopoietic stem cells will be a people who encounter this situation. You can use cure in case of graft against the host. However, if the drug has no effect, transplant patients against the risk of causing injury to the internal organs and even lead to death.


The treatment of cancer, such as chemotherapy or radiation therapy before transplantation makes the immune system weakened significantly, resulting in a body prone to infections. The doctor will prescribe you some medications to help prevent bacterial as well as virus intrusion when you perform a bone marrow transplant.

Diseases related to digestive system

Chemo therapy before the transplant can cause nutritional problems because it makes your appetite as well as cause diarrhoea or vomiting.

Disease thrombophlebitis

Vein occlusion is one of the complications of bone marrow transplantation. This condition causes damage to the blood vessels in the liver. According to experts statistics, every 20 transplant recipients hematopoietic stem cells will be a person suffering from thrombophlebitis.


According to statistics from the doctor after receiving a bone marrow transplant, the patient is no longer capable of child birth. The cause is mainly due to side effects from the drug dose chemotherapy as well as radiation treatment that you use before conducting implant surgery.

Stem cell transplantation hematopoietic failure: the worst case

When successful transplant, new blood cells and healthy will be produced continuously. At this time, sickle cell disease has been treat the root. The success rate of this method of treatment is 90%, meaning that out of every 10 implant surgeries will have up to 9 songs to bring good results.

However, if you hit situations the worst is implant failure, the doctor will repeat the process to try to treat definitively for you. Isolated cases, they will proceed together with stem cells of your own for you. This means that sickle cell disease are at high risk will relapse.

The article of Hello Health Group and Hello Doctor only for reference, not a substitute for the diagnosis or treatment of medical.

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