Transplant patients against: edged to from a bone marrow transplant -

Transplant patients against: edged to from a bone marrow transplant

Transplant patients anti home is one of the common complication of a bone marrow transplant. We can help you prevent cancer relapse, but also potentially life-threatening you.

If you’ve undergone surgery, bone marrow transplant, also called stem cell transplant hematopoietic, you will certainly want to learn as well as keep track of the signs of the disease graft against the host (GvHD). This is a common complication of transplant of hematopoietic stem cells, there are up to four in five people implanted faced with this health condition.

Transplant patients against, what is?

Transplant patients against, occurs when the cells from the donor attack cells of the you do confuse them with foreign body invade (pathogens). This disease can be mild, but if there is no medical intervention timely, it is capable of threatening you.

Fact, disease graft against the host can also bring benefits for you. If the immune cells of the donor attack healthy cells of you, we will also destroy any cancer cells left in the body after stem cell transplant. In special cases such doctor will decide the best measure is to not treat this complication.

Symptoms of disease of the graft against the host

Transplant patients anti-can appear in a number of different parts on your body. Usually, it will affect the skin, digestive system or your liver. It often begins with symptoms of rash, itching in the palms and soles of the feet. You can also experience nausea, vomiting or diarrhea.

However, you should note that some of the above symptoms can be a side effect of a bone marrow transplant or medications after surgery. Sometimes, they also mean that you are infection. For accurate diagnosis, the doctor will perform a biopsy by taking a piece of tissue in areas in the body affected model tests. The expert will use a microscope to search for signs of the disease graft against the host.

Based on the symptoms, disease graft against the host is divided into two main types:

Transplant patients against acute

This type usually occurs within 100 days since transplant hematopoietic stem cells. Usual symptoms of this group are:

  • Rashes in the palms and soles of the feet, ears, face or shoulder. It can spread at breakneck speed. Your skin may be blistered and peeling.
  • Diarrhea, abdominal cramps, nausea, vomiting or anorexia.
  • Waste accumulates in the liver causing skin and your eyes are yellow.
  • The number of erythrocytes or platelets significantly reduced.
  • High fever.

Transplant patients against chronic

This group usually appear after the acute type occurs. If you have disease graft against acute, the more likely you will be faced with this type in the next time. Sometimes, both happen at the same time.

Rash and digestive problems are also symptoms of the disease graft against the host chronic. In addition, this situation also manifest many other symptoms, such as:

  • Dry eyes, discomfort and sensitivity to light
  • Dry mouth and esophagus, which can lead to sores
  • Joint pain
  • Thick leather, darker in color, brittle nails and hair loss
  • Dry the vagina and feel the stimulation (women)
  • Wheezing and persistent cough

Disease graft against the host is divided into phases and different levels based on the severity of the symptoms. The stages and levels this helps the doctor easily decide treatments and can also be a sign that likely you will recover.

The cause of the disease graft against the host

During chemotherapy, the stem cells inside the bone marrow have the task of producing blood cells is destroyed along with the cancer cells. The bone marrow transplant or stem cells from a donor lets your body create new blood cells. However, when the disease graft against the host occurs, the cells of the donor can attack the healthy cells of you as if they were bacteria or viruses, harmful intrusion into the body.

The principal cause of this problem is due to your body is not compatible with the donor. In addition, a number of factors other small also has the ability to cause an increased risk of disease graft against the host, including:

  • Age: the older you get, the percentage of compatibility as low, resulting in the risk of disease as high.
  • The bone marrow donor contains more T cells – a type of leukemia cells.
  • Other gender: the recipient may be men and who donate back is women with children.
  • Cytomegalovirus development (a type of common virus usually does not cause problems if you healthy).

When performing the bone marrow transplantation, the percentage of compatibility between you and the donor as large as possible. If you don’t have twins, normally the body you will be most compatible with siblings and parents. Of course, there are also cases body you compatible good with strangers. The risk of occurrence of disease graft against the host will also decrease if doctors get hematopoietic stem cells from umbilical cord rather than peripheral blood or bone marrow.

Use medicines as directed by your doctor before and after transplantation of hematopoietic stem cells can help you prevent disease graft anti-host. You will also receive prescription of immunosuppressive drugs to avoid transplant rejection.

Treatment of disease graft against the host

If the doctor identify disease transplant anti-host has developed to the level of need for treatment, they will probably prescribe you a corticosteroid medication such as prednisone and immunosuppressive drugs like cyclosporine. These things have disadvantages as make your body more vulnerable to infections, so you will also have to take antibiotics prophylactically.

The other treatments can help you control the symptoms in specific parts of the body, for example:


You can get a type of steroid cream to treat itchy rashes. Let’s moisturize your skin and protect it before the sun.

The digestive system

Your body will quickly lose water when diarrhea is severe. Avoid spicy foods or acidic are good options at this point. In the worst case, you may need to be translated or to be fed through a tube to keep the weight. You will also have to limit fat, until the intestines recover.


You can use mouthwash dedicated to cleansing and moisturizing the oral cavity.


Artificial tears or drops of steroids has anti-dry and keep your eyes not scratched.

The immune system

At this time you should stay away from the crowd, as well as limited access to patients because your body very prone to infection. You should also avoid gardening and go horizontal area not clean. In particular, you do not get in contact with someone recently vaccinated.

Transplant patients against strains typically will disappear automatically after one year since surgery. When that your body was able to start the self-reproduction of blood cells from stem cells are grafted into. However, isolated cases will have a number of people have to live with it for many years.

The article of Hello Health Group and Hello Doctor only for reference, not a substitute for the diagnosis or treatment of medical.

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